Gonzo has not only had to come to terms with the loss of his entire family, but he also barely survived being shot in the chest multiple times while still a human, and was later turned into a werewolf during a vicious attack while hiking as he tried to put his life back together.
Constance has had her own losses, and while nowhere near as bad as Gonzo's, they've left a mark on her as well. She's determined to live her life without a partner though, because her two sexual experiences in college convinced her she's asexual.
Gonzo's a biker people cross the road to avoid, while Constance has multiple doctorate degrees and works as a research scientist for a leading pharmaceutical firm. Gonzo doesn't trust women, Constance has no use for men -- and yet they're going to find themselves working toward the same goals.
Can they form a team to do what needs to be done?